QT time prolongation
Adverse drug events
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Explanations of the substances for patients
We have no additional warnings for the combination of abarelix and ivosidenib. Please also consult the relevant specialist information.
The reported changes in exposure correspond to the changes in the plasma concentration-time curve [ AUC ]. We do not expect any change in exposure for abarelix, when combined with ivosidenib (100%). We do not expect any change in exposure for ivosidenib, when combined with abarelix (100%).
The pharmacokinetic parameters of the average population are used as the starting point for calculating the individual changes in exposure due to the interactions.
The bioavailability of abarelix is unknown. The terminal half-life [ t12 ] is rather long at 316.8 hours and constant plasma levels [ Css ] are only reached after more than 1267.2 hours. The protein binding [ Pb ] is 97.5% strong. The metabolism via cytochromes is currently still being worked on.
The bioavailability of ivosidenib is unknown. Protein binding [ Pb ] is not known. The metabolism mainly takes place via CYP3A4 and the active transport takes place in particular via PGP.
|Serotonergic Effects a||0||Ø||Ø|
Rating: According to our knowledge, neither abarelix nor ivosidenib increase serotonergic activity.
|Kiesel & Durán b||0||Ø||Ø|
Rating: According to our knowledge, neither abarelix nor ivosidenib increase anticholinergic activity.
QT time prolongation
Rating: In combination, abarelix and ivosidenib can potentially trigger ventricular arrhythmias of the torsades de pointes type.
General adverse effects
|Side effects||∑ frequency||aba||ivo|
|Elevated alkaline phosphatase||27.0 %||n.a.||27.0|
|Elevated AST||27.0 %||n.a.||27.0|
Hypophosphatemia (25%): ivosidenib
Fever (23%): ivosidenib
Elevated serum creatinine (23%): ivosidenib
Cough (22%): ivosidenib
Vomiting (21%): ivosidenib
Constipation (20%): ivosidenib
Stomatitis (10%): ivosidenib
Hyperbilirubinemia (16%): ivosidenib
Elevated ALT (15%): ivosidenib
Headache (16%): ivosidenib
Paresthesia (10%): ivosidenib
Peripheral neuropathy (10%): ivosidenib
Hypotension (12%): ivosidenib
Angina pectoris (10%): ivosidenib
Allergic skin reactions like pruritus and rash (10%): ivosidenib
Arthralgia (10%): ivosidenib
Myalgia (10%): ivosidenib
Tumor lysis syndrom: ivosidenib
Based on your answers and scientific information, we assess the individual risk of undesirable side effects. These recommendations are intended to advise professionals and are not a substitute for consultation with a doctor. In the restricted test version (alpha), the risk of all substances has not yet been conclusively assessed.
No literature information available.