QT time prolongation
Adverse drug events
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Explanations of the substances for patients
We have no additional warnings for the combination of abarelix and tazemetostat. Please also consult the relevant specialist information.
The reported changes in exposure correspond to the changes in the plasma concentration-time curve [ AUC ]. We do not expect any change in exposure for abarelix, when combined with tazemetostat (100%). We do not expect any change in exposure for tazemetostat, when combined with abarelix (100%).
The pharmacokinetic parameters of the average population are used as the starting point for calculating the individual changes in exposure due to the interactions.
The bioavailability of abarelix is unknown. The terminal half-life [ t12 ] is rather long at 316.8 hours and constant plasma levels [ Css ] are only reached after more than 1267.2 hours. The protein binding [ Pb ] is 97.5% strong. The metabolism via cytochromes is currently still being worked on.
The bioavailability, half-life, and volume of distribution of tazemetostat are unknown to us.
|Serotonergic Effects a||0||Ø||Ø|
Rating: According to our knowledge, neither abarelix nor tazemetostat increase serotonergic activity.
|Kiesel & Durán b||0||Ø||Ø|
Rating: According to our knowledge, neither abarelix nor tazemetostat increase anticholinergic activity.
QT time prolongation
Rating: In combination, abarelix and tazemetostat can potentially trigger ventricular arrhythmias of the torsades de pointes type.
General adverse effects
|Side effects||∑ frequency||aba||taz|
|Musculoskeletal pain||52.0 %||n.a.||52.0|
Cough (18%): tazemetostat
Dyspnea (16%): tazemetostat
Abdominal pain (16.5%): tazemetostat
Diarrhea (16%): tazemetostat
Hypokalemia (16%): tazemetostat
Hyponatremia (16%): tazemetostat
Hypophosphatemia (16%): tazemetostat
Anemia (16%): tazemetostat
Acute myeloid leukemia: tazemetostat
Myelodysplastic syndrome: tazemetostat
Elevated transaminases (16%): tazemetostat
Weight loss (16%): tazemetostat
Elevated serum creatinine (14%): tazemetostat
Based on your answers and scientific information, we assess the individual risk of undesirable side effects. These recommendations are intended to advise professionals and are not a substitute for consultation with a doctor. In the restricted test version (alpha), the risk of all substances has not yet been conclusively assessed.
No literature information available.