QT time prolongation
Adverse drug events
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Explanations of the substances for patients
We have no additional warnings for the combination of abarelix and trifluoperazine. Please also consult the relevant specialist information.
The reported changes in exposure correspond to the changes in the plasma concentration-time curve [ AUC ]. We do not expect any change in exposure for abarelix, when combined with trifluoperazine (100%). We do not expect any change in exposure for trifluoperazine, when combined with abarelix (100%).
The pharmacokinetic parameters of the average population are used as the starting point for calculating the individual changes in exposure due to the interactions.
The bioavailability of abarelix is unknown. The terminal half-life [ t12 ] is rather long at 316.8 hours and constant plasma levels [ Css ] are only reached after more than 1267.2 hours. The protein binding [ Pb ] is 97.5% strong. The metabolism via cytochromes is currently still being worked on.
The bioavailability of trifluoperazine is unknown. The terminal half-life [ t12 ] is 15 hours and constant plasma levels [ Css ] are reached after approximately 60 hours. Protein binding [ Pb ] is not known. The metabolism does not take place via the common cytochromes and the active transport takes place in particular via UGT1A4.
|Serotonergic Effects a||0||Ø||Ø|
Rating: According to our knowledge, neither abarelix nor trifluoperazine increase serotonergic activity.
|Kiesel & Durán b||1||Ø||+|
Recommendation: As a precaution, attention should be paid to anticholinergic symptoms, especially after increasing the dose and at doses in the upper therapeutic range.
Rating: Trifluoperazine only has a mild effect on the anticholinergic system. The risk of anticholinergic syndrome with this medication is rather low if the dosage is in the usual range. According to our knowledge, abarelix does not increase anticholinergic activity.
QT time prolongation
Rating: In combination, abarelix and trifluoperazine can potentially trigger ventricular arrhythmias of the torsades de pointes type.
General adverse effects
|Side effects||∑ frequency||aba||tri|
|Orthostatic hypotension||1.0 %||n.a.||+|
Blurred vision: trifluoperazine
Ineffective thermoregulation: trifluoperazine
Neuroleptic malignant syndrome: trifluoperazine
Tardive dyskinesia: trifluoperazine
Urinary retention: trifluoperazine
Thromboembolic disorder: trifluoperazine
Based on your answers and scientific information, we assess the individual risk of undesirable side effects. These recommendations are intended to advise professionals and are not a substitute for consultation with a doctor. In the restricted test version (alpha), the risk of all substances has not yet been conclusively assessed.
No literature information available.