QT time prolongation
Adverse drug events
|Upper respiratory infection|
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Abatacept has been used since 2005 to treat autoimmune diseases such as rheumatoid arthritis and psoriatic arthritis. It is given subcutaneously. Abatacept is a fusion protein (composed protein molecule) from the extracellular (outside of the cell body) part of the human T lymphocyte antigen-4 (CTLA-4) and the modified Fc part of the human immunoglobulin G1 (IgG1). It reduces the activity of T lymphocytes (a type of white blood cell) by interrupting the signal cascade that activates them (binding to CD80 and CD86). In this way, inflammatory reactions directed against the body's own tissue are interrupted.
The warnings are checked for the combination of several active substances. For the individual substances, please consult the relevant specialist information.
Since only abatacept was entered without any further substances, no pharmacokinetic interaction can be detected.
The pharmacokinetic parameters of the average population are used as the starting point for calculating the individual changes in exposure due to the interactions.
The bioavailability, half-life, and volume of distribution of abatacept are unknown to us.
|Serotonergic Effects a||0||Ø|
Rating: According to our knowledge, abatacept does not increase serotonergic activity.
|Kiesel & Durán b||0||Ø|
Rating: According to our knowledge, abatacept does not increase anticholinergic activity.
QT time prolongation
We do not know of any QT-prolonging potential for abatacept.
General adverse effects
|Side effects||∑ frequency||aba|
|Upper respiratory infection||10.0 %||10.0|
|Abdominal pain||1.0 %||+|
|Elevated transaminases||1.0 %||+|
Urinary tract infection: abatacept
Based on your answers and scientific information, we assess the individual risk of undesirable side effects. These recommendations are intended to advise professionals and are not a substitute for consultation with a doctor. In the restricted test version (alpha), the risk of all substances has not yet been conclusively assessed.
No literature information available.