Summary
72%
Pharmacokinetic
|
0% | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Aldesleukin |
Scores | 0% | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
QT time prolongation
| |||||||||||
Anticholinergic effects
| |||||||||||
Serotonergic effects
|
Adverse drug events
|
-28% | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Diarrhea | |||||||||||
Shivering | |||||||||||
Vomiting |
Variants ✨
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Pharmacokinetics
-0%
∑ Exposurea | ald | |
---|---|---|
Aldesleukin | 1 |
Legend (n.a.): Information not available
Since only aldesleukin was entered without any further substances, no pharmacokinetic interactions can be detected.
Rating:
The pharmacokinetic parameters of the average population are used as the starting point for calculating the individual changes in exposure due to the interactions.
The bioavailability of aldesleukin is unknown. Protein binding [Pb] is not known. The metabolism does not take place via the common cytochromes.
Serotonergic effects
-0%
Scores | ∑ Points | ald |
---|---|---|
Serotonergic Effects a | 0 | Ø |
Rating: According to our knowledge, aldesleukin does not increase serotonergic activity.
Anticholinergic effects
-0%
Scores | ∑ Points | ald |
---|---|---|
Kiesel b | 0 | Ø |
Rating: According to our findings, aldesleukin does not increase anticholinergic activity.
QT time prolongation
-0%
We do not know of any QT-prolonging potential for aldesleukin.
General adverse effects
-28%
Side effects | ∑ frequency | ald |
---|---|---|
Diarrhea | 67.0 % | 67.0 |
Shivering | 52.0 % | 52.0 |
Vomiting | 50.0 % | 50.0 |
Rash | 42.0 % | 42.0 |
Hyperbilirubinemia | 40.0 % | 40.0 |
Thrombocytopenia | 37.0 % | 37.0 |
Nausea | 35.0 % | 35.0 |
Dyspnea | 35.0 % | 35.0 |
Confusion | 34.0 % | 34.0 |
Elevated serum creatinine | 33.0 % | 33.0 |
Sign (+): side effect described, but frequency not known
Sign (↑/↓): frequency rather higher / lower due to exposure
Hematological
Anemia (29%): aldesleukin
Systemic
Fever (29%): aldesleukin
Malaise (27%): aldesleukin
Cardiac
Peripheral edema (28%): aldesleukin
Tachycardia (23%): aldesleukin
Myocardial infarction: aldesleukin
Hypotension: aldesleukin
Supraventricular tachycardia: aldesleukin
Dermatological
Pruritus (24%): aldesleukin
Neurological
Asthenia (23%): aldesleukin
Somnolence (22%): aldesleukin
Gastrointestinal
Loss of appetite (20%): aldesleukin
Vascular
Capillary leak syndrome: aldesleukin
Limitations
Based on your
References
No literature information available.