QT time prolongation
Adverse drug events
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Alectinib is used in anaplastic lymphoma kinase (ALK) -positive, advanced non-small cell lung cancer (NSCLC) in adult patients. It is taken orally as a capsule. Alectinib is an anti-tumor agent from the group of protein kinase inhibitors, more precisely the tyrosine kinase ALK (anaplastic lymphoma kinase). This enzyme is modified in patients with NSCLC and stimulates tumor growth. Alectinib blocks the activity of the ALK and thus also slows down tumor growth. As edema, constipation, diarrhea, nausea, muscle pain, anemia (too few red blood cells), increased creatinine levels, alanine transferase (ALT) and aspartate aminotransferase (AST).
The warnings are checked for the combination of several active substances. For the individual substances, please consult the relevant specialist information.
Since only alectinib was entered without any further substances, no pharmacokinetic interactions can be detected.
The pharmacokinetic parameters of the average population are used as the starting point for calculating the individual changes in exposure due to the interactions.
The bioavailability, half-life, and volume of distribution of alectinib are unknown to us.
|Serotonergic Effects a||0||Ø|
Rating: According to our knowledge, alectinib does not increase serotonergic activity.
|Kiesel & Durán b||0||Ø|
Rating: According to our findings, alectinib does not increase anticholinergic activity.
QT time prolongation
We do not know of any QT-prolonging potential for alectinib.
General adverse effects
|Side effects||∑ frequency||ale|
|Peripheral edema||30.0 %||30.0|
|Elevated transaminases||14.5 %||14.5|
|Weight gain||12.0 %||12.0|
Bradycardia (8.9%): alectinib
Blurred vision (8.6%): alectinib
Elevated serum creatinine (7.2%): alectinib
Renal failure: alectinib
Elevated alkaline phosphatase (6.2%): alectinib
Stomatitis (3%): alectinib
Interstitial lung disease: alectinib
Based on your
No literature information available.